The issue usually began at about 85,800 miles when owners noticed the check engine light coming on. Jun 13, 2017 - Philadelphia, PA - Engine. 2006 was the very first year they used this engine in the E-Series vehicles, and the engines have been re-engineered since then. The 2006 Mercedes-Benz E350 has 135 NHTSA complaints for the fuel/propulsion system at 93,675 miles average. THE VEHICLE WAS TOWED TO AN INDEPENDENT MECHANIC, BUT WAS NOT DIAGNOSED OR REPAIRED. WHILE DRIVING 5 MPH, THE VEHICLE STALLED AND THE STOP BRAKING SYSTEM WARNING INDICATOR ILLUMINATED AND FLASHED. Learn what owners have to say and get authentic consumer feedback before buying your next car. Get reliability information for the 2006 Mercedes-Benz E-Class from Consumer Reports, which combines extensive survey data and expert technical knowledge. 5 liter v6. The biggest problem owners reported with the 2006 Mercedes-Benz E350 was with the 24-valve DOHC 3.5-liter V6 engine in the 2006 E350. TL* THE CONTACT OWNS A 2006 MERCEDES-BENZ E350. Our list of 45 known complaints reported by owners can help you fix your 2006 Mercedes-Benz E350. Worst 2006 Mercedes-Benz E350 Problems #1: Balance Shaft Failure 2006 E350 Average Cost to Fix: $4,800 Average Mileage: 85,000 mi. Problem with Engine. Learn More #2: Leaking Fuel Tank Gasket 2006 E350 … Problem with your 2006 Mercedes-Benz E350? Read consumer reviews from real 2006 Mercedes-Benz E-Class buyers. My car is the base model which, for 2006, was outfitted with a 3. 2006 Mercedes-Benz E-Class My Mercedes is a very reliable vehicle as it is still running strong. I have a had problems with the brakes and fuel pump as well as a slew of electrical problems; however, this is expected at two hundred thousand miles for any luxury vehicle.