Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Riobó P, Paz B, Franco JM, Vázquez JA, Murado MA, Cacho E: Mouse bioassay for palytoxin. The quality and correctness of the information submitted to ECHA remains the responsibility of the data submitter. Cite this article. Specific symptoms and dose-response against dose-death time relationships. Water Res. The ‘Hazard classification’ and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. 2005, 245: 149-161. disinfectants, pest control products) and washing & cleaning products. 4-phenyl benzoic acid. This site is not fully supported in Internet Explorer 7 (and earlier versions). © 2020 BioMed Central Ltd unless otherwise stated. If at least one company has indicated that the substance classification is affected by impurities or additives, this will be indicated by an informative sentence. Toxicological dynamics, kinetics, ouabain inhibition and thermal stability. Use the links below to find out how this reactive group interacts with any m Previous works have reported the importance of the concentration of carboxylic acid exposures in suppressing the growth of bacteria [7, 26–28]. Some substance identifiers may have been claimed confidential, or may not have been provided, and therefore not be displayed. Fitting procedures and parametric estimates from the experimental results were performed by minimisation of the sum of quadratic differences between observed and model-predicted values, using the nonlinear least-squares (quasi-Newton) method provided by the macro 'Solver' of Microsoft Excel 2003 spreadsheet. Office of Response and Restoration, https://doi.org/10.1186/1475-2859-10-100, DOI: https://doi.org/10.1186/1475-2859-10-100. The molecular structure is based on structures generated from information available in ECHA’s databases. Bjornsdottir K, Breidt F, McFeeters RF: Protective effects of organic acids on survival of Escherichia coli O157:H7 in acidic environments. This substance is used in the following products: pH regulators and water treatment products, leather treatment products, polymers and laboratory chemicals. and v 50,τ This mathematical model was formulated by the combination of the Weibull equation for dose-response description and the logistic equation for bacterial growth in a bivariate model. Appl Environ Microbiol. 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ECHA maintains the C&L Inventory, but does not review or verify the accuracy of the information. Vázquez, J.A., Durán, A., Rodríguez-Amado, I. et al. Our results revealed that the toxicity of carboxylic acids almost always decreased (higher value of EC 50,τ) with increasing of their molecular weights but not depending on pK a value. Indolecarboxylic acids and derivatives are compounds containing a carboxylic acid group (or a derivative thereof) linked to an indole. More information about the EC Inventory can be found here. In all cases, distribution of residuals was randomly scattered around zero and grouped data and autocorrelations were not observed. This parameter was defined as the dose of agent (in mM) that reduces the biomass by 50% compared to that produced by the control at time (τ) that reduces the biomass by 50% [22]. 2-Indolecarboxylic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa). Article It covers their hazardous properties, classification and labelling, and information on how to use them safely. It is the responsibility of the substance manufacturers and importers to consult official publications, e.g. NSC 23040. http://www.bowdoin.edu/~rdelevie/excellaneous/, http://creativecommons.org/licenses/by/2.0. Boziaris IS, Skandamis PN, Anastasiadi M, Nychas GJE: Effect of NaCl and KCl on fate and growth/no growth interfaces of Listeria monocytogenes Scott A at different pH and nisin concentrations. Ross T: Indices for performance evaluation of predictive models in food microbiology. ways because they are similar in their chemical structure. Bowmer CT, Hooftman RN, Hanstveit AO, Venderbosch PWM, van der Hoeven N: The ecotoxicity and the biodegradability of lactic acid, alkyl lactate esters and lactate salts. However, we have demonstrated that the effects and toxicity of carboxylic acids can be successfully compared and significant kinetic parameters can be obtained. For instance, formic acid was more toxic for La growth than for the production of biomass by Bs. 2009, 49: 510-515. Please note that it may take a week or two to have everything fully in place, and please be aware in the meantime that the Registration status may be incorrect and the CLP regulatory context may be incompletely shown. Giotta L, Agostiano A, Italiano F, Milano F, Trotta M: Heavy metal ion influence on the photosynthetic growth of Rhodobacter sphaeroides. statement and In that case, the ATP (Adaptation to Technical Progress) number is displayed. volume 10, Article number: 100 (2011) 2006, 72: 660-664. Appl Environ Microbiol. The Waste Framework Directive aims to protect the environment and human health from the generation and management of waste and to improve efficient use of resources. Keys for bacteria are described in Table 7. Keys for bacteria are described in Table 7. The authors declare that they have no competing interests. InfoCards are generated automatically based on the data available at the time of generation. For relative viable cell count, an assumption was established: when (N/N0) data were < 1 then values of ln (N/N0) were forced to zero. Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. 1999, 87: 907-914. Each substance with Tam VH, Schilling AN, Nikolaou M: Modelling time-kill studies to discern the pharmacodynamics of meropenem. Murado MA, González MP, Vázquez JA: Dose-reponse relationships. Smaller carboxylic acids (1 to 5 carbons) are soluble in water, whereas bigger carboxylic acids have limited solubility due to the increasing hydropho…