Published August 31. Diffusion Time Calculator. All values are … Ensure adequate hydration before administration. FineTunedUniverse.com. Description: This calculator determines the infusion time for an electronically control regulator for IVs. In this blog post, I use two NAPLEX type IV flow rate calculations questions to show you how to calculate infusion time given the drop factor and the IV flow rate. Drip rate (mL/hour) = Total volume (mL) / Infusion time. Volume = 250 mL. History of anaphylactic or severe systemic hypersensitivity reactions to subcutaneous administration of human IG. May be managed using oxygen therapy with adequate ventilatory support. SCIg60 Infusion System. Passive transfer of antibodies may transiently interfere with the immune responses to live attenuated virus vaccines (e.g., measles, mumps, rubella and varicella). Drip rate = (Drops per minute * 60) / Drop factor. Emergency Medications Calculator. The following information is intended to assist HCPs in selection of appropriate equipment in order to achieve the maximum infusion rate of 60 mL/h/site with CUVITRU. US Food and Drug Administration. 300 Shire Way, Lexington, MA 02421. infusion time (hr) = total volume (mL) ÷ flow rate (mL/hr) total volume (mL) = flow rate (mL/hr) × infusion time (hr) For example, if you must administer 1 L (1,000 mL) of fluid over 4 hours, use the first formula to calculate the flow rate, like so: flow rate (mL/hr) = total volume (mL) ÷ infusion time (hr) Up to 4 sites simultaneously may be used.1. TAKEDA and the TAKEDA logo are trademarks or registered trademarks of Takeda Pharmaceutical Company Limited. OnePath is a registered trademark of Shire, a Takeda Company. Ensure patients are not volume depleted prior to starting infusion. Lexington, MA: Baxalta US Inc. 2. IgA-deficient patients with antibodies to IgA are at greater risk of developing potentially severe hypersensitivity reactions, including anaphylaxis. If suspected, perform appropriate tests for presence of anti-neutrophil and anti-HLA antibodies in both product and patient serum. 501(K) Premarket Notification K173738. Calculate the infusion time. Transfusion-Related Acute Lung Injury: Non-cardiogenic pulmonary edema may occur with IV administered IG. In the below Volume/Time - IV mL Rate Calculator, enter the values for Volume of the fluid passed in cubic … Follow each infusion pump’s manufacturer guidelines before use and administration. Thrombosis: May occur following treatment with IG products and in the absence of known risk factors. In patients at risk due to pre-existing renal insufficiency or predisposition to acute renal failure, assess renal function before initiation and throughout treatment, and consider lower, more frequent dosing. US Food and Drug Administration. Aseptic Meningitis Syndrome: Has been reported with use of IG and may occur more frequently in females. *CUVITRU: Maximum volume per site is 60 mL/site as tolerated (except for the first 2 infusions for patients <40 kg). 501(K) Premarket Notification. 1-800-828-2088. Hemolysis: CUVITRU contains blood group antibodies which may cause a positive direct antiglobulin reaction and hemolysis. Interference with Lab Tests: False positive serological test results and certain assay readings, with the potential for misleading interpretation, may occur as the result of passively transferred antibodies. Accessed September 27, 2019. No confirmed cases of viral transmission or variant Creutzfeldt-Jakob disease (vCJD) have been associated with CUVITRU. Risk factors may include advanced age, prolonged immobilization, hypercoagulable conditions, history of venous or arterial thrombosis, use of estrogens, indwelling vascular catheters, hyperviscosity and cardiovascular risk factors. Published December 14, 2018. select "No IV pump" volume = 250 mL rate = 33 gtt/min calibration = 10 gtt/mL. From a physiological perspective, this knowledge helps us better understand how long it takes molecules and ions to travel physiologically relevant distances by diffusion alone. CUVITRU [Prescribing Information]. Please click for Full Prescribing Information. Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk for hyperviscosity. Thrombosis may occur with immune globulin (IG) products, including CUVITRU. Please expand for Indication and Important Safety Information. The answer is 8 hours. There are 250 mL of D 5 W infusing at 33 (gtt/min) on IV tubing calibrated at 10 drops/milliliter (gtt/mL). Ensure adequate hydration in patients before administration. Transmittable Infectious Agents: Because CUVITRU is made from human plasma, it may carry a risk of transmitting infectious agents (e.g., viruses, other pathogens). Infusion time is the total amount of time the liquid is administered. Monitor patients for signs and symptoms of hemolysis and delayed hemolytic anemia and, if present, perform appropriate confirmatory lab testing. The volumetric flow rate, also known as volume flow rate or the volume velocity is the volume of fluid which passes through a given cross-sectional area per unit time. Renal Dysfunction/Failure: Acute renal dysfunction/failure, acute tubular necrosis, proximal tubular nephropathy, osmotic nephrosis and death may occur with intravenous (IV) use of IG products, especially those containing sucrose. IgA-deficient patients with antibodies against IgA and a history of hypersensitivity to human IG. Back To AnyCalculator.com. However, the drip rate can also be calculated using the drop rate formula (this function is available in the advanced mode of our gtt in min calculator): Drip rate = Drops per hour / Drop factor, or. Conduct a thorough neurological exam on patients exhibiting signs and symptoms to rule out other causes of meningitis. Knowing how to calculate infusion time is extremely important when administering intravenous (IV) infusions. All rights reserved. All other product brands or trademarks appearing herein are the property of their respective owners. For patients at risk of thrombosis, administer CUVITRU at the minimum dose and infusion rate practicable. Calculations are based on a 28-day month and assumes the maximum volume per site and maximum infusion rate after the first two infusions. When considering the diffusion of ions and molecules in solutions, it is generally useful to be able to estimate the time required for diffusion over a given distance. Actual formula: 250 / ( 33 gtt/min 10: x 60) = 1.26 Hours: 0.26 x 60 = 16 minutes So 1.26 Hours = 1 Hour & 16 minutes. Use the infusion calculator to explore CUVITRU [Immune Globulin Subcutaneous (Human)] 20% Solution administration parameter combinations for your patients based on needlesticks and frequency of infusions, and help your patients achieve CUVITRU’s maximum infusion rate by selecting the proper supplies. In patients at risk, administer at the minimum dose and infusion rate practicable. IV tubing calibration = 10 gtt/mL. CUVITRU is indicated as replacement therapy for primary humoral immunodeficiency (PI) in adult and pediatric patients ≥2 years. A simple online IV Infusion Rate Calculator to calculate the Volume/Time mL Rate for the given volume of fluid passed and the time. This tool does not provide treatment recommendations or infusion parameters. CUVITRU is for subcutaneous use only. 1 Calculations are based on a 28-day month and assumes the maximum volume per site and maximum infusion rate after the first two infusions. Discontinuing IG treatment has resulted in remission within several days without sequelae. Regulated IVs are also known infusion and syringe pumps. CUVITRU and MYIGSOURCE are trademarks or registered trademarks of Baxalta Incorporated, a Takeda company. Hypersensitivity: Severe hypersensitivity reactions may occur, even in patients who have tolerated previous treatment with human IG. All values are rounded up to the nearest whole number. Maximum infusion rate is 60 mL/hr/site as tolerated (after first 2 infusions). If a hypersensitivity reaction occurs, discontinue infusion immediately and institute appropriate treatment. For more information, contact a Takeda representative. HIgH-Flo Subcutaneous Safety Needle Sets™. Integrated Catch-Up Freedom Syringe Driver Infusion System. Takeda does not prefer, recommend, or attest to using any specific infusion pump or other ancillary devices. 250 mL × 10 ( 33 × 60 min) The answer is 1.26 hours. ©2020 Takeda Pharmaceutical Company Limited. Maximum infusion rate is 60 mL/hr/site as tolerated (after first 2 infusions). Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk of hyperviscosity. gtt/min = 33 gtt/min. Monitor patients for pulmonary adverse reactions. Up to 4 sites simultaneously may be used. Explore administration combinations and supplies, Achieving an optimal experience requires appropriate supplies, Use to achieve the maximum flow rate of 60 mL/hr/site. It is crucial to set the drip rate very carefully! The most common adverse reactions observed in clinical trials in ≥5% of patients were: local adverse reactions including mild or moderate pain, erythema, and pruritus, and systemic adverse reactions including headache, nausea, fatigue, diarrhea, and vomiting. Note: IV stands for intravenous. Recently I had open heart surgery at a local hospital. If renal function deteriorates, consider discontinuation. Calculate the infusion time.